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Metronidazole
Infants & Children

Infants & Children

General Dosing

Use PO when possible

10 mg/kg/dose PO tid Usual adult dose: 500mg PO q8h Dose limit: 2 g/day PO

  • 10 mg/kg/dose IV q8h Usual adult dose: 500mg IV q8h

OR

  • 7.5 mg/kg/dose IV q6h Dose limit: 4 g/day IV

Perforated Appendicitis

Use of once daily Metronidazole is indicated only for Perforated Appendicitis due to limited evidence

30mg/kg/dose IV q24h

Dose limit:

  • ≤80 kg: 1 g/dose
  • >80kg: 1.5g/dose

Helicobacter pylori associated ulcer

15-24 kg

250 mg PO bid

25-34 kg

500 mg PO in the morning, 250 mg PO in the evening

≥35 kg

500 mg PO bid

Ulcerative colitis, Crohn's Disease:

  • 3.3-6.7 mg/kg/dose IV tid

OR

  • 3.3-6.7 mg/kg/dose PO tid after meals

OR

  • 5-10 mg/kg/dose PO bid after meals

Usual adult dose: 500mg/dose Dose limit: 1.5 g/day

Other Indications

Giardiasis

5 mg/kg/dose PO tid (maximum 750 mg/day) x 5 days or single daily dose as follows:

  • <25 kg: 35 mg/kg/dose PO once daily x 3 days
  • 25-40 kg: 50 mg/kg/dose PO once daily x 3 days
  • >40 kg: 2 g/dose PO once daily x 3 days
Amoebiasis

12-17 mg/kg/dose PO tid x 5-10 days Dose limit: 2.25g/day

*Trichomonas vaginalis*

For patients older than 13 years: 2g PO Once

Gut sterilization pre-operative preparation

10 mg/kg/dose PO

  • Give at 1300h, 1400h, and 2300h starting the day prior to surgery
Treatment of intestinal bacterial overgrowth (SIBO)

10 mg/kg/dose PO BID to TID