Prevention of emerging resistant organisms

• Meningitis or encephalitis

• Brain abscess

• VP shunt infection

• Neurosurgical patients with subdural grids

• Sepsis in infants >1 month of age

• Sickle cell disease patients presenting with Fever (rule out infection) in the Emergency Dept.

• Acute osteomyelitis in sickle cell disease patients

• Severe or complicated community acquired bacterial pneumonia

• Perforated appendicitis

• Moderate to severe aspiration pneumonia

• Gonorrhea, pelvic inflammatory disease

• Orbital cellulitis

• Lyme disease

• Typhoid fever

Neisseria meningitidis where rifampin is contraindicated

Infectious Diseases approval is required