Meropenem (Merrem®)

Meropenem (Merrem®)




General Information

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

Restriction: Restricted to ID expert or designee

Criteria for Use:

  • Documented infection with ESBL-producing organism
  • Gram negative infection, including Pseudomonas aeruginosa, with resistance/failure to cefepime and/or piperacillin/tazobactam, and other broad-spectrum antimicrobials
  • Febrile neutropenia with penicillin or cephalosporin allergy

Advisory: Extended-infusion dosing over 3 hours has been utilized

  • Immediate and delayed-type allergy
  • GI disturbance
  • Cytopenias, positive Coombs
  • Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic