Restricted
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility
Associated with more treatment failures than alternatives and excess mortality - Only use when alternatives are not suitable
Note: Pseudomonas and Proteus vulgaris are inherently resistant
COMMON
SERIOUS
Non-formulary; requires a non-formulary drug request
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
pH: 7.8