Antimicrobials
Tigecycline

Tigecycline

Restricted

Medium
N/A

Spectrum of Activity

Dosing

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility

Associated with more treatment failures than alternatives and excess mortality - Only use when alternatives are not suitable

Note: Pseudomonas and Proteus vulgaris are inherently resistant

  • Warfarin: may enhance the anticoagulant effect of warfarin. Monitor therapy
  • Oral contraceptives

COMMON

  • Diarrhea, nausea, vomiting

SERIOUS

  • Acute pancreatitis

Non-formulary; requires a non-formulary drug request

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

pH: 7.8