Antimicrobials
Moxifloxacin

Moxifloxacin

High
Excellent

Spectrum of Activity

Dosing

General Information

HEALTH CANADA APPROVED

  • Treatment of a variety of severe infections including: community acquired pneumonia, complicated intra-abdominal or skin and skin structure infections, caused by susceptible organisms.
  • NOT a first-line agent
  • Other drugs that prolong QTc interval
  • Divalent cations including Ca, Mg - Decreased absorption
  • Warfarin - increased INR
  • Rifampin - decrease moxifloxacin levels

Requires Special Authorization for PEI Pharmacare (except for the Cystic Fibrosis program)

Monitor QTc in patients with increased risk

  • Avoid dairy products, antacids, and other sources of divalent cations (Ca, Fe, Mg, Al, Zn) which can chelate levofloxacin and prevent absorption
  • Must hold continuous tube feeding 2 h before and 2 h after administration

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic