Antimicrobials
Imipenem-Cilastatin

Imipenem-Cilastatin

Medium
N/A

Spectrum of Activity

Dosing

General Information

  • Severe hospital acquired infections or patients with risk factors for multi-drug resistance where broad spectrum coverage is required
  • Meropenem should usually be used instead
  • May decrease serum concentrations of valproic acid
  • Ganciclovir/Valganciclovir - May increase risk of seizures

Seizure risk

  • Immediate or delayed hypersensitivity reactions
  • C. difficile
  • Neurotoxicity

Meropenem preferred for CNS infections and when CrCl less than 30 mL/min

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Use meropenem

Biliary penetration: Therapeutic