Restricted
HEALTH CANADA APPROVED
Note: HEALTH PEI has restricted the use of DAPTOmycin
Not indicated for use in pneumonia since its activity is inhibited in the presence of pulmonary surfactant
HMG-CoA reductase inhibitors: increased risk of developing myopathy. Consider temporarily stopping HMG-CoA reductase inhibitor therapy prior to DAPTOmycin
RECOMMENDED
HEALTH PEI has restricted the use of DAPTOmycin:
Antimicrobial class: Cyclic Lipopeptide Antibiotic
Pregnancy category: B
Average serum half life: 9 hours
Urine penetration: Therapeutic
Lung penetration: Poor
CSF penetration: Poor
pH: 6.8 (Cubicin RF)