Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate

Spectrum of Activity

Dosing

General Information

  • Urethritis/cervicitis: Chlamydia and gonorrhea (in combination with 3rd gen cephalosporin)
  • Pertussis
  • Nontuberculous mycobacteria: prophylaxis (advanced HIV infection) and treatment (in combination with other medications)
  • Bartonella infections
  • Legionella infections

Alternative:

  • Bacterial COPD exacerbation
  • Acute otitis media
  • Bacterial conjunctivitis
  • Pelvic inflammatory disease (in combination)
  • Salmonella, Shigella, traveler’s diarrhea
  • Cesarean section (non-elective) prophylaxis
  • Drugs that may prolong the QTc interval: possible additive effect. Avoid concurrent use
  • Increases cyclosporine levels
  • May increase digoxin levels
  • Increased risk of rhabdomyolysis with statins
  • Prolonged QTc interval and Torsades de Pointes
  • Potential for drug-drug interactions

IM administration: not recommended; extravasation of the drug into the tissues may cause tissue damage

Antimicrobial class: Macrolide antibiotic

Pregnancy category: B

Average serum half life: 68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic