Empirical therapy for presumed fungal infection in febrile, neutropenic patients
Treatment of aspergillosis, candida, and/or cryptococcus infections refractory to conventional amphotericin B or when renal impairment or unacceptable toxicity precludes use of conventional amphotericin B
Other nephrotoxic drugs: Concomitant use may enhance amphotericin B nephrotoxicity (eg vancomycin, aminoglycosides, pentamidine, cycloSPORINE, CISplatin)
Loop/thiazide diuretics, long term steroids, laxatives; increased risk for hypokalemia/hypomagnesemia; recommend amiloride. Monitor potassium closely. May still need additional potassium supplementation