Antimicrobials
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Excellent

Dosing

General Information

  • Primary: Polymicrobial infections with no other oral therapeutic options, either alone or in combination.
  • Prophylaxis (when indicated) and treatment of human and animal bite wounds.

Increased risk of rash with allopurinol.

For prolonged therapy, monitor liver enzymes and function.

  • Allergy/rash (immediate or delayed)
  • Note EBV related rash
  • Cytopenias
  • Diarrhea (less likely with twice daily dosing regimen using 875 mg tab)
  • C. difficile
  • Hepatotoxicity due to clavulinate - usually mild, liver failure is rare

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic