Antimicrobials
erythromycin

erythromycin

Low
Moderate
$0.2(250mg TAB) $30(1g INJ)

Dosing

General Information

  • For most indications, azithromycin or clarithromycin are preferred

  • Motility agent

  • As part of a combination therapy for bowel preparation for colorectal surgery

  • Nausea/vomiting (25%)

  • Diarrhea (8%)

  • Prolonged QT interval and Torsades de Pointes

  • Substrate of CYP3A4. Multiple CYP450 interactions possible

  • Caution with QTc prolonging medications

  • May increase digoxin and carbemazepine levels

  • Statins: risk rhabdomyolysis

Monitor QTc in patients with increased risk.

250 mg TAB: $0.2

1 g (20 mL) VIAL: $30

500 mg (10 mL) VIAL: $18

Antimicrobial Class: Macrolide

Route of Elimination: Primarily hepatic

Adapted from the Horizon Health Network Antimicrobial Stewardship Program