Antimicrobials
fluconazole

fluconazole

Low
Excellent
$1(50mg TAB) $10(200mg INJ)

Spectrum of Activity

Dosing

General Information

  • Candida infections both mucocutaneous and invasive - i.e. Candidemia
  • Cryptococcus and Coccidioides infections
  • Antifungal prophylaxis in immunocompromised
  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

  • Many via CYP450. Suggest review specific patient medications
  • Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics
  • Risk when combining with other QTc prolonging medications

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

50 mg TAB: $1

200 mg (100 mL) VIAL: $10

400 mg (200 mL) MINIBAG: $20

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic

ODB Coverage: General Benefit (50-100 mg TAB), LU (150 mg TAB & SUSP)

Adapted from the Markham Stouffville Hospital Antimicrobial Stewardship Program