Antimicrobials
sulfamethoxazole-trimethoprim

sulfamethoxazole-trimethoprim

Low
Excellent (90 to 100%)
$0.2(800-160mg TAB)

Dosing

General Information

  • Urinary tract infections

  • Susceptible MRSA infections

  • Stenotrophomonas infections

  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

  • Gastrointestinal upset common

  • Bone marrow suppression

  • Hyperkalemia

  • Renal failure

  • Hepatitis

  • Aseptic meningitis

  • Stevens Johnson syndrome/toxic epidermal necrolysis

  • Other rashes

  • ACEi - Increased serum potassium level
  • Increases amantadine levels
  • Decreases cyclosporine
  • Methotrexate - Marrow suppression
  • Increases phenytoin
  • Increases rifampin
  • Increases INR with warfarin

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia. CBC periodically.

400-80 mg TAB: $0.1

800-160 mg TAB: $0.2

400-80 mg/5 mL AMP: $7.15

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

5:1 ratio (SMX:TMP) is constant in all forms.

ODB Formulary: General Benefit (TAB)