Skin and Soft Tissue Infections


  • Non-purulent cellulitis is mostly caused by beta-hemolytic streptococci (e.g. Group A streptococci) or MSSA

  • Purulent cellulitis can be caused by MRSA. Specimens should be obtained for microbiologic diagnosis

  • Colonization with MRSA does NOT justify anti-MRSA treatment

  • An important aspect of treatment is to keep the affected extremity elevated

  • Improvement of erythema can take days, especially in patients with lymphedema

  • 5 to 10 days of therapy is often adequate for the SSTI listed below

  • Consider tetanus immunity status

More Information

Guideline adapted from Providence Health Care

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