Enterobacter cloacae
General Susceptibility

General Susceptibility

Carbapenem until susceptibility known, then step down to aminoglycoside or fluoroquinolone if susceptible.

Note that Enterobacter species have a chromosomal AmpC beta-lactamase. While appearing susceptible to 3rd generation cephalosporins (such as cefotaxime) on testing, they become resistant during therapy in about 10-20% of cases (Chow, Annals Int Med 115:585-590 1991). For this reason, carbapenems are often used to treat invasive Enterobacter infections