Trimethoprim-sulfamethoxazole
Neonatal Route/Dilution

Neonatal Route/Dilution

Route

IV, PO

Final Dilution

IV

1.6 mg/mL (as trimethoprim)

Dilution Instructions

Prepare just prior to administration

Mix 18mL of D5W with 2mL of undiluted trimethoprim/ sulfamethoxazole (16 mg/mL TMP and 80 mg/mL SMX) in a 30 mL empty sterile vial = 1.6 mg/mL (as trimethoprim)

Stability

16 mg/mL (trimethoprim) = 12 H (after first use) at room temperature
1.6 mg/mL (trimethoprim) = 1.5H at room temperature