Trimethoprim-sulfamethoxazole
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: PO Dosing (EGFR)

0 - 30 eGFR
  • 1 - 2 DS tab daily OR
  • If normal dose is 1 DS tab BID: 1 DS tab followed by 1 SS tab BID
  • If normal dose is 2 DS tab BID: 1 DS tab BID
30+ eGFR

No dosage adjustment required.

Not On Dialysis: IV Dosing

Depends on indication and and originally recommended dose. Consult pharmacy.