3.375 IV q6h
Severe Pseudomonas infections: 4.5 g IV q6h
IV
40 mg/mL in NS (Piperacillin)
Supplied by pharmacy
24H room temperature
0 - 30 eGFR30 - 50 eGFR50+ eGFR2.25 g IV q6 - 8h2.25 - 3.375 g IV q6hNo dosage adjustment required.
Extend dosing interval in infants with renal dysfunction. Consult NICU pharmacist for dosing recommendations
Broad spectrum agent with anti-pseudomonal activity used for severe infections including sepsis, pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia.
Pregnancy: Compatible.
Breastfeeding: Compatible.
Scr (particularly if on other nephrotoxic agents ie. vancomycin)
CBC
Liver enzymes
Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes, GI intolerance (diarrhea)
Can cause prolonged bleeding time, prolonged partial thromboplastin time, prolonged prothrombin time
Can increase the risk of nephrotoxicity when given with vancomycin.
Higher doses required for antipseudomonal coverage (4.5 g IV q6h)
Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor.