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Antimicrobials
Piperacillin-Tazobactam

Piperacillin-Tazobactam

C difficile risk
Medium
Oral Bioavailability
N/A

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

3.375 IV q6h

Severe Pseudomonas infections: 4.5 g IV q6h

Neonatal

Neonatal Route/Dilution

IV

40 mg/mL in NS (Piperacillin)

Supplied by pharmacy

24H room temperature

Renal

0 - 30 eGFR30 - 50 eGFR50+ eGFR2.25 g IV q6 - 8h2.25 - 3.375 g IV q6hNo dosage adjustment required.

Extend dosing interval in infants with renal dysfunction. Consult NICU pharmacist for dosing recommendations

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including sepsis, pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia.

Pregnancy and Lactation

Pregnancy: Compatible.

Breastfeeding: Compatible.

Drug Monitoring

  • Scr (particularly if on other nephrotoxic agents ie. vancomycin)

  • CBC

  • Liver enzymes

Adverse Effects

  • Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes, GI intolerance (diarrhea)

  • Can cause prolonged bleeding time, prolonged partial thromboplastin time, prolonged prothrombin time

Major Interactions

Can increase the risk of nephrotoxicity when given with vancomycin.

Additional Information

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor.