Piperacillin-Tazobactam
C difficile risk
Medium
Oral Bioavailability
N/A
Dosing
0 - 30 eGFR30 - 50 eGFR50+ eGFR2.25 g IV q6 - 8h2.25 - 3.375 g IV q6hNo dosage adjustment required.
Extend dosing interval in infants with renal dysfunction. Consult NICU pharmacist for dosing recommendations
General Information
Broad spectrum agent with anti-pseudomonal activity used for severe infections including sepsis, pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia.
Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes, GI intolerance (diarrhea)
Can cause prolonged bleeding time, prolonged partial thromboplastin time, prolonged prothrombin time
