Klebsiella pneumoniae (C&W)



General Information

Broad spectrum agent with anti-pseudomonal activity used for severe infections including sepsis, pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia.

Pregnancy: Compatible.

Breastfeeding: Compatible.

  • Scr (particularly if on other nephrotoxic agents ie. vancomycin)
  • CBC
  • Liver enzymes
  • Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes, GI intolerance (diarrhea)
  • Can cause prolonged bleeding time, prolonged partial thromboplastin time, prolonged prothrombin time

Can increase the risk of nephrotoxicity when given with vancomycin.

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor.