In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.
If worsening renal function, actual GFR is likely lower than calculated.
If improving renal function, actual GFR is likely higher than calculated eGFR.
Not On Dialysis: STANDARD DOSING (eGFR)
500 - 1000 mg IV q24h
500 - 1000 mg IV q12h
500 - 1000 mg IV q8h
No dose adjustment required.
Not On Dialysis: MENINGITIS (eGFR)
2 g IV Q24H
2 g IV Q12H
No dosage adjustment required.