Meropenem
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: STANDARD DOSING (eGFR)

0 - 10 eGFR

500 - 1000 mg IV q24h

10 - 25 eGFR

500 - 1000 mg IV q12h

25 - 50 eGFR

500 - 1000 mg IV q8h

50+ eGFR

No dose adjustment required.

Not On Dialysis: MENINGITIS (eGFR)

0 - 10 eGFR

2 g IV Q24H

10 - 50 eGFR

2 g IV Q12H

50+

No dosage adjustment required.

Neonatal

Increase dosing interval in renal impairment