Pregnancy: Very limited data. Due to the known safety of other beta lactams in pregnancy, likely compatible.
Breastfeeding: Very limited data. Imipenem seems to transfer into breastmilk in very low amounts. In the information available currently, it does not appear cilastatin transfers into breastmilk in detectable amounts.
Treatment of infections caused by multi-drug resistant gram negative organisms.
Non formulary
Cilastatin prevents renal metabolism of imipenem by competitive inhibition of dehydropeptidase along the brush border of the renal tubules.
Antimicrobial class: Carbapenem