Spectrum Of Activity
100 mg PO BID
Skin and soft tissue infection
Methicillin resistant staphylococcus aureus (MRSA) infections
Community acquired pneumonia
Sexually transmitted infections
Pelvic inflammatory disease
Doxycycline itself is unlikely associated with an increased risk of congenital malformations, reduced fetal bone growth or teeth staining with in utero exposure, however, is usually avoided during pregnancy because of the associations of these adverse events with other tetracyclines (particularly in the second and third trimester).
Tetracyclines might induce hepatic necrosis in some pregnant women, however, this is a rare syndrome most commonly associated with intravenous dosing of tetracyclines.
Doxycycline can be used during breastfeeding for short courses (ie. up to 3 weeks) as this has not been associated with infant dental staining.
Longer courses (ie. greater than 3 weeks) or repeat courses should be avoided as a precaution.
GI upset and erosive esophagitis
Di- & Trivalent cations including Al, Ca, Fe, Mg (anatacids, dairy products, iron supplements, some enteral feeds) - decreases doxycycline absorption
Some anticonvulsants can decrease doxycycline levels
Increased digoxin levels
Increased INR with warfarin
May exacerbate muscle weakness in persons with myasthenia gravis
Antimicrobial class: Tetracycline