Ciprofloxacin - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

<10 eGFR

250 - 500 mg PO daily

10 - 30 eGFR

500 - 750 mg PO daily

30+ eGFR

500 - 750mg PO BID

0 - 30 eGFR

400 mg IV q24h

30+ eGFR

400 mg IV q8 - 12h

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