Cephalexin

C difficile risk
Medium
Oral Bioavailability
Excellent

Dosing

500 - 1000 mg PO QID

500 mg PO TID x 48h (in combination with metronidazole 500 mg PO TID)

12.5 to 25 mg/kg/day given as a single daily dose or in divided doses PO Q12H

PO

50 mg/mL

Reconstitution instructions for 250 mg/5 mL powder for oral suspension: 1. Shake bottle to loosen powder 2. Add 60mL of sterile water in 2 portions to make a final volume of 100mL. Shake well in between additions of water 3. Shake well

50 mg/mL = 14 days Refrigerate

0 - 10 eGFR10 - 30 eGFR30 - 50 eGFR50+ eGFR500 mg PO daily to BID500 mg PO BID to TID500 mg PO TID to QID500 - 1000 mg PO QID

General Information

  • Skin and soft tissue infection

  • MSSA infections

  • Urinary tract infections

Pregnancy: Compatible.

Breastfeeding: Compatible.

  • Allergy/rash (immediate or delayed).

  • Gastrointestinal intolerance.

  • Can cause positive Coombs, cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities.

Amoxicillin and ampicillin share a common structural side chain with cephalexin, therefore, there is an increased risk of cross allergy between these agents.

  • Please see penicillin and beta lactam allergy management and cross reactivity tool.

Increases metformin levels.

Antimicrobial class: First generation cephalosporin - oral

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