Cephalexin - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 10 eGFR

500 mg PO daily to BID

10 - 30 eGFR

500 mg PO BID to TID

30 - 50 eGFR

500 mg PO TID to QID

50+ eGFR

500 - 1000 mg PO QID

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