Spectrum Of Activity
1 - 2 g IV q24h
2 g IV q12h
In combination with IV ampicillin2 g IV q12h
250 mg IM x 1 dose (in combination with azithromycin 1 g po x 1 dose)
Ceftriaxone is contraindicated if they require (or are expected to require) treatment with calcium-containing IV solutions, including TPNInfuse over 30 minutes
Age 0-4 wk50 mg/kg/dose IV Q24H
Age 0-7 daysAge 8-28 days50 mg/kg/dose IV Q24H50 mg/kg/dose IV Q24H
Age 0-7 daysAge 8-28 days50 mg/kg/dose IV Q24H75 mg/kg/dose IV Q24H
All Infants: 75 mg/kg/dose IV Q24H
Reconstitute 250mg vial with 4.9mL of sterile water for injection = 50 mg/mL
Empiric therapy of bacterial meningitis.
Empiric therapy of nosocomial Gram negative infections (except Pseudomonas).
Empiric therapy of hospitalized community or nursing home acquired pneumonia.
Empiric therapy of spontaneous bacterial peritonitis.
Empiric treatment of pyelonephritis.
Gonorrhea (in combination with azithromycin).
Consider alternative to ceftriaxone (ie. cefotaxime) at the time of delivery (particularly in preterm delivery) to minimize exposure to newborn.
Allergy/rash (immediate or delayed)
Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
Pseudocholelithiasis - unclear clinical significance - uncommonly symptomatic, but frequently found by ultrasound gallbladder sludge
Ceftriaxone should not be diluted or administered simultaneously with any calcium-containing solution via a Y-site in any patient. However, ceftriaxone and calcium-containing solutions may be administered sequentially of one another for use in patients other than neonates if infusion lines are thoroughly flushed (with a compatible fluid) between infusions.
Fatal lung and kidney damage associated with calcium-ceftriaxone precipitates has been observed in premature and term neonates. Due to reports of precipitation reaction in neonates, do not reconstitute, admix, or coadminister with calcium-containing solutions, even via separate infusion lines/sites or at different times in any neonate.
Antimicrobial class: Parenteral Cephalosporin - 3rd Generation