Firstline - Clinical Decisions

C difficile risk High

Oral Bioavailability N/A

Spectrum of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Neonatal

Neonatal Route/Dilution

Renal

General Information

Common Usage

Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection, musculoskeletal i.e. septic arthritis, and urinary tract infection.

Pregnancy and Lactation

Pregnancy: Compatible.

Breastfeeding: Compatible.

Adverse Effects

Rash, localized phlebitis at injection site, allergy.
Positive Coombs test, neutropenia, abnormalities in liver enzymes.
Diarrhea and CDI.

Additional Information

Cefotaxime is the preferred 3rd generation cephalosporin vs ceftriaxone in pregnant patients near delivery (particularly preterm delivery) to minimize ceftriaxone exposure in the newborn.

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin