Cefotaxime
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (eGFR)

0 - 30 eGFR

1 - 2 g IV q12 - 24h

30 - 50 eGFR

1 - 2 g IV q8 - 12h

50+ eGFR

1 - 2 g IV q6 - 8h

Neonatal

Increase dosing interval in renal impairment