Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

1- 2 g IV q4 - 6h

2 g IV q4h

2 g IV q6h x 48h (in combination with IV erythromycin)

Infuse over 3-5 minutes

Age 0-4wkMeningitis50 mg/kg/dose IV Q12H100 mg/kg/dose Q12H

Age 0-7 days>7 daysMeningitis50 mg/kg/dose IV Q12H50 mg/kg/dose IV Q8HAge 0-7 days: 100 mg/kg/dose IV Q12H Age > 7 days: 100 mg/kg/dose IV Q8H

Age 0-7 days>7 daysMeningitis50 mg/kg/dose IV Q8H50 mg/kg/dose IV Q6HAge 0-7 days: 100 mg/kg/dose IV Q8H Age > 7 days: 75 mg/kg/dose IV Q6H

MeningitisAll Infants: 50 mg/kg/dose IV Q6H75 mg/kg/dose IV Q6H

IVIM50 mg/mL250 mg/mL

IVIMReconstitute 250mg vial with 5mL of sterile water for injection = 50 mg/mLReconstitute 250mg vial with 0.9mL of SWI = 250 mg/mL

1 hour at room temperature and 4 hours refrigerated

0 - 25 eGFR25 - 50 eGFR50+ eGFR1- 2 g IV q8 - 12h 1 - 2 g IV q6 - 8h1 - 2 g IV q4 - 6h

Increase dosing interval in renal impairment

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Used as part of the preterm prelabour rupture of membranes (PPROM) protocol.

Pregnancy: Compatible

Breastfeeding: Compatible

Allergy and rash as for all beta-lactams. EBV related rash (not allergy).

Rare: cytopenias

  • Contraindicated in patients with true penicillin allergies.

  • Ampicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reaction between these agents.

    • Please refer to penicillin and beta lactam allergy management tool and cross reactivity table.

Antimicrobial class: aminopenicillin

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