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Amoxicillin-Clavulanate

C difficile risk
Medium
Oral Bioavailability
Excellent

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

875/125 mg PO BID or 500/125 mg PO TID

Renal

<10 eGFR10 - 30 eGFR30+ eGFR250 - 500 mg amoxicillin component daily - BID (do not use 875 mg tablet, if eGFR <30)250 - 500 mg amoxicillin component po BID (do not use 875 mg tablet if eGFR <30)875 mg PO BID or 500 mg PO TID of the amoxicillin component

General Information

Common Usage

  • Prophylaxis/treatment of bite wounds

  • Polymicrobial infections of the respiratory tract or abdomen

  • Skin and soft tissue infections

Pregnancy and Lactation

Pregnancy: Amoxicillin/clavulanic acid may be associated with NEC in the newborn if given near delivery in the setting of PPROM

Breastfeeding: Compatible

Drug Monitoring

For prolonged therapy monitor liver enzymes, CBC

Adverse Effects

  • Gastrointestinal side effects - diarrhea

  • Hepatotoxicity due to clavulanate - usually mild, liver failure is rare

  • Allergy/rash (immediate or delayed), cytopenias

    • Note EBV related rash

Major Interactions

  • Contraindicated in patients with true penicillin allergies.

  • Amoxicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reactivity between this agents.

    • Please see penicillin and beta lactam allergy management tool and cross reactivity table.

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

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