Amoxicillin-Clavulanate - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

<10 eGFR

250 - 500 mg amoxicillin component daily - BID (do not use 875 mg tablet, if eGFR <30)

10 - 30 eGFR

250 - 500 mg amoxicillin component po BID (do not use 875 mg tablet if eGFR <30)

30+ eGFR

875 mg PO BID or 500 mg PO TID of the amoxicillin component

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