Amoxicillin

C difficile risk
Low
Oral Bioavailability
Excellent

Dosing

Oral: 500 -1000 mg TID

Following IV ampicillin and erythromycin x 48 hOral: 250 mg TID x 5 days (in combination with oral erythromycin)

Shake bottle well before using

5 to 20 mg/kg/day PO given as a single daily dose or in divided doses Q12H

PO

50 mg/mL

Reconstitution instructions for 250 mg/5 mL powder for oral suspension: 1. Shake bottle to loosen powder 2. Add 68mL of sterile water to the bottle to make a total volume of 100mL 3. Shake bottle well

50 mg/mL = 14 daysRefrigerate

General Information

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for respiratory tract infections and urinary tract infections.

Used as part of the preterm prelabour rupture of membranes (PPROM) protocol after 48 h of IV ampicillin and erythromycin administration.

Pregnancy: Compatible.

Breastfeeding: Compatible.

  • Gastrointestinal side effects

  • Allergy/rash (immediate or delayed), cytopenias

    • Note EBV related rash

  • Contraindicated in patients with true penicillin allergies.

  • Amoxicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reactivity between these agents.

    • Please see penicillin and beta lactam allergy management document and cross reactivity table.

Antimicrobial class: Aminopenicillin

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