Consult pharmacy for all patients receiving amikacin for level interpretation and dose individualization.
Monitor creatinine at least 2-3 times/week.
Formal audiology assessment should be done if planning to use amikacin for 2 weeks or longer or if any symptoms develop.
Inform patient of risk of otoxocity and to report any symptoms.
Once daily dosing: Pre-dose serum drug levels should be negligible (less than 1 mg/L). Peak levels not required.
Multiple daily dosing: Serum drug levels are recommended around the third dose following initial therapy or any change in dose
- Pre-dose level: 0 to 30 minutes before next dose should be less than 10 mg/L
- Post-dose level: 30 minutes after completion of an IV infusion should be 25 to 30 mg/L