Antimicrobials
Ketoconazole

Ketoconazole

General Information

Neonatal: Perform periodic liver function tests and monitor patient for evidence of adrenal insufficiency

Neonatal:

  • Hepatotoxicity
  • Nausea/vomiting
  • Adrenal cortical insufficiency (reported with high doses in adults)

Neonatal:

  • Increases serum levels of the following drugs:
    • Phenytoin
    • Theophylline
    • Cyclosporine
    • Warfarin
  • Decreases serum levels of the following drugs:
    • Rifampin
    • Isoniazid
  • Decreased GI absorption when administered with H₂ blocker or antacid

Neonatal:

Topical: 2% topical cream PO: 20 mg/mL compounded oral suspension

  • Tablets require adequate gastric acidity for dissolution
    • In patients receiving H₂-antagonists (e.g. ranitidine) or proton pump inhibitors (e.g. omeprazole) administer ketoconazole with a cola beverage
  • Do not administer with antacids (space doses by 2 hrs)