Zidovudine

C difficile risk
N/A
Oral Bioavailability
Excellent

Dosing

Intrapartum - initiate IV zidovudine immediately at ROM, onset of labour, or at least 2 hours prior to cesarean section2 mg/kg/dose IV STAT once THEN 1 mg/kg/h IV continuous infusion until cord clamped

Use guideline Infant of Mother with HIV when ordering zidovudine. More information, as well as online physician order forms, can be found at HIV/AIDS Clinical Guidelines (http://www.bcwomens.ca/health-professionals/professional-resources/hiv-aids-resources/hiv-aids-clinical-guidelines)

Note: Infuse over 60 minutes

PO, IV

PO: 10 mg/mL IV: 1 mg/mL

Mix 1mL of 10 mg/mL concentration with 9mL of D5W or NS in a 10mL empty sterile vial = 1 mg/mL

10 mg/mL = 24 hours (after first use) 1 mg/mL = 24 hours Room Temperature

General Information

Prevention of perinatal HIV transmission.

Pregnancy: Compatible.

Breastfeeding: Breastfeeding is not recommended in the setting of HIV infection.

Headache GI intolerance Rash Anemia Neutropenia Thrombocytopenia Increased liver enzymes

Antimicrobial class: Antiretroviral; NRTI

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