Indicated as first line agent for invasive fungal infections by Aspergillus spp
Monitor weekly voriconazole serum trough concentrations every TUESDAY (levels are processed every Thursday morning at St. Paul's Hospital).
Target trough concentrations: 1 to 5.5 mg/L.
Steady-state concentrations require at least four days after onset of treatment or change in dose.
Invasive fungal infections by Aspergillus spp
Multiple, serious/life-threatening drug interactions involving the cytochrome P450 enzymes; check with pharmacy before initiating or stopping voriconazole therapy
Bioavailability 80%
Antimicrobial class: Triazole antifungal, second generation
Average serum half life: Variable and dose dependent
Route of Elimination: Urine (<2% as unchanged drug)