Antimicrobials
Doxycycline

Doxycycline

Low
Excellent
$0.20/day

General Information

  • Lyme disease. Refer to BCCH Lyme Disease Treatment Algorithm for further guidance
  • Skin and soft tissue infection
  • Methicillin resistant staphylococcus aureus infections
  • Doxycycline may be less likely to cause teeth staining than tetracycline. Teeth staining is dose related, so duration of therapy should be minimized
  • Photosensitivity may occur (avoid prolonged exposure to sunlight)

Avoid iron, calcium and dairy products for at least one hour before or two hours after doxycycline administration

  • Capsules: 100mg
  • Injection: 100 mg/vial (available through the Special Access Program only)

Not recommended for use in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth unless alternative agents not available (eg. Anthrax, rickettsial disease, or ehrlichiosis)

Antimicrobial class: Tetracycline

Average serum half life: No data for pediatrics. Adults: 18 to 22 hours

Route of Elimination: In the urine (23-40%) and feces (30%)