Restricted to treatment of severe infections caused by resistant Gram-positive organisms, where other agents cannot be used.
Please refer to restriction guidelines.
Monitor creatine phosphokinase at baseline and once weekly during therapy
Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR
Injection: 500 mg vial
Recommend Infectious Disease Consult
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection
Limited information available for daptomycin use in infants
Antimicrobial class: Cyclic lipopeptide
Average serum half life: Neonates and Infants <3 months: 6.2 hours Children: 5 to 7 hours
Route of Elimination: 78% of the dose excreted in urine as unchanged drug; feces (6%)