Antimicrobials
Daptomycin

Daptomycin

Low
N/A
IV: $$$

Spectrum of Activity

General Information

Restricted to treatment of severe infections caused by resistant Gram-positive organisms, where other agents cannot be used.
 

Please refer to restriction guidelines.

Monitor creatine phosphokinase at baseline and once weekly during therapy

Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR

Injection: 500 mg vial

Recommend Infectious Disease Consult

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection

Limited information available for daptomycin use in infants

Antimicrobial class: Cyclic lipopeptide

Average serum half life: Neonates and Infants <3 months: 6.2 hours Children: 5 to 7 hours

Route of Elimination: 78% of the dose excreted in urine as unchanged drug; feces (6%)