Antimicrobials
Caspofungin

Caspofungin

Low
N/A
IV: $$$$

Spectrum of Activity

General Information

Therapy of suspected and confirmed invasive fungal infections

Adverse effects include:

  • Elevated transaminases
  • Fever
  • Rash
  • Pruritus
  • Phlebitis
  • Headache
  • GI symptoms
  • Anemia
  • Caspofungin levels/effects may be increased with concurrent use of cyclosporine and decreased with rifampin
  • Caspofungin may reduce AUC of tacrolimus by ~20%

Injection: 50 mg/vial

  • Achieves low levels in CSF; caspofungin is not recommended for CNS disease
  • Less than 2% of dose is excreted into urine in unchanged form; treatment failures of candiduria due to potentially subtherapeutic concentrations in urine have been reported

Antimicrobial class: Echinocandin