General Information
Pediatric:
- Injection: 1,200,000 IU/2 mL PLS
Neonatal:
- IM: 1,200,000 units/2 mL pre-loaded syringe (PLS)
- Do not inject into or near artery or nerve (may result in neurovascular and neurological damage)
- Not a substitute for IV penicillin G; used in certain situations only; consult ID service
- Warming to room temperature will lessen pain on injection
- Provides sustained levels for 2-4 weeks
- Therapeutic alternative in neonates who have normal physical examination, radiographic imaging, and laboratory analyses (includes infant RPR/VDRL titre ≤4 times maternal RPR/VDRL) but are at risk of infection from inadequate maternal therapy; used in certain situations only, consult ID service
- RPR: rapid plasma reagin
- VDRL: venereal disease research laboratory