Antimicrobials
Itraconazole

Itraconazole

General Information

Consider therapeutic drug monitoring of trough levels if prolonged treatment duration for invasive fungal disease is needed

  • Nausea and vomiting
  • Hypertriglyceridemia
  • Hypokalemia
  • Elevated hepatic aminotransferases
  • Grapefruit decreases itraconazole absorption whereas acidic beverages such as colas or cranberry juice enhances absorption
  • Potent inhibitor of CYP3A4 enzyme with many important drug interactions
  • Capsule: 100mg
  • Oral solution: 10 mg/mL
  • Oral solution and capsule dosage should not be used interchangeably
  • Administer capsules immediately after a full meal for maximal absorption. Oral solution should be taken on an empty stomach (1 hour before or 2 hours after meals) for maximal absorption