Antimicrobials
Colistimethate

Colistimethate

N/A
N/A
IV: $$

Spectrum of Activity

General Information

Nephrotoxic and neurotoxic when given systemically

Injection: 150 mg/vial

  • Injectable form is used for inhalation: prepare by reconstituting vial with 3mL of normal saline (= 50 mg/mL)
    • Further dilute dose with normal saline for nebulization
    • Stable for 24 hours, refrigerated
  • For IV dosing in CF: higher doses 5-8 mg/kg/24 hours may be required for resistant organisms, however, higher doses are associated with more severe toxicity