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Guidelines
Enterococcus Species

Enterococcus Species

Empiric Treatment

Vancomycin as per order set 10-111-5335: Initiation of Vancomycin for Adult Inpatients
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  • Order set link found in vancomycin monograph
  • Notify pharmacist for levels and further dosing

Once Susceptibilities Known

Ampicillin 2 g IV Q4H
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1st line, if susceptible and no allergy

OR

CONTINUE Vancomycin as per pharmacist and trough levels
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2nd line, if allergy or resistance

Vancomycin Resistant Enterococci (VRE)

OR

Duration and De-escalation

Duration:

  • Uncomplicated (removable source): minimum 2 weeks from first negative blood culture
  • Complicated (e.g. endocarditis, osteomyelitis, unremovable source or bacteremia that persists more than 72 hours on appropriate therapy): requires 6 weeks of therapy