Empiric Treatment

Empiric Treatment


Choice of empiric treatment is based on severity of illness, likely organism(s), and risk factors for infection

Antibiotics can be withheld in hemodynamically stable patients & no other source of infection pending blood culture results, except for:

  • Immunocompromised patients
  • Critically ill patients
  • Prosthetic valve(s) or other hardware in place
  • Purulence at the catheter site
  • Severe sepsis
  • Neutropenia
  • Hospitalization for >72 hours

In patients with an alternative infectious diagnosis (e.g., pneumonia) who have a central line consider adding vancomycin pending cultures

Empiric Treatment

  • Order set link found in vancomycin monograph
  • Notify pharmacist for levels and further dosing

When Covering Gram Negatives

See Risk Factors for Gram Negatives above