Bacteremia - Central Line Associated

Bacteremia - Central Line Associated


Central lines include: 

  • PICCs
  • Port-a-caths
  • Dialysis catheter
  • Arterial lines
  • Intra-jugular & subclavian
  • Hickman catheters

Organism-Specific Therapy

Empiric Therapy - Do not narrow antibiotics until organism identity +/- susceptibilities are available

Organism-Specific Therapy - Consult susceptibilities once available to optimize therapy

Additional Information

Guideline originally sourced from Saskatchewan Health Authority - Saskatoon Area and adapted by Joseph Brant Hospital

  • Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1.

  • O'Grady NP, Alexander M, Burns LA, et al. Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis. 2011;52(9):1087-1099.

  • Doern GV, Carroll KC, Diekema DJ, et al. A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem. Clin Microbiol Rev. 2019;33(1):e00009-19. Published 2019 Oct 30.

  • Pien BC, Sundaram P, Raoof N, et al. The clinical and prognostic importance of positive blood cultures in adults. Am J Med. 2010;123(9):819-828.

  • Punjabi C, Tien V, Meng L, Deresinski S, Holubar M. Oral Fluoroquinolone or Trimethoprim-sulfamethoxazole vs. ß-lactams as Step-Down Therapy for Enterobacteriaceae Bacteremia: Systematic Review and Meta-analysis [published online ahead of print, 2019 Aug 14]. Open Forum Infect Dis. 2019;6(10):ofz364.

  • The Johns Hopkins University (2020) John Hopkins ABX Guide (1.27) [Mobile App] Retrieved from:

  • Antimicrobial Therapy Inc (2020) The Sanford Guide (4.2) [Mobile App] Retrieved from:

Adapted from the Joseph Brant Hospital Antimicrobial Stewardship Program