Screen for osteomyelitis
S. aureus
Streptococcus sp.
Enterobacteriaceae
Anaerobes
Ceftriaxone 2 g IV q24h x 4 days then reassess
PLUS
Metronidazole 500 mg PO BID x 4 days then reassess
OR
Pip-Tazo 3.375 g IV q6h x 4 days then reassess
Meropenem 1 g IV q8h x 4 days then reassess
Ertapenem 1 g IV q24h x 4 days
Then reassess for oral step down therapy options
Doxycycline 100 mg PO BID x 4 days then reassess
TMP-SMX 2 DS tabs PO BID x 4 days then reassess
Vancomycin 25 mg/kg IV load, then 15 mg/kg IV q8 to 12h x 4 days
Then reassess for oral step down therapy
