Restricted
Restricted: for use in HIV/AIDS, transplant, hematology, oncology, or ophthalmology patients.
FDA Treatment Recommendations: Cytomegalovirus infections.
CBC including platelet count and serum creatinine at baseline and periodically during therapy.
Monitoring more frequently in patients with renal impairment, previous drug-induced leukopenia and those with ANC less than 1 on treatment initiation.
Potential to cause birth defects in humans
Hypertension
Headache, insomnia
Diarrhea, nausea, vomiting and abdominal pain
Anemia, thrombocytopenia, neutropenia
Tremor
Retinal detachment
Increased serum creatinine
May increase levels of:
Amphotericin B
Imipenem
Mycophenolate
Tenofovir products
Zidovudine
Valganciclovir is a prodrug of ganciclovir with excellent bioavailability, equivalent to that of IV ganciclovir and much better than oral ganciclovir.