Antimicrobials
Voriconazole

Voriconazole

Restricted

Low
Excellent (90 to 100%)

Spectrum of Activity

Dosing

General Information

Restricted to prophylaxis or treatment of aspergillus OR scedosporium OR fusarium OR in patients intolerant to or isolate resistant to amphotericin B deoxycholate or fluconazole.

Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (Discuss with ID).

QTc interval in patients at elevated risk.

Monitor hepatic profile.

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • Visual disturbance
  • Fluorosis
  • GI upset
  • CYP450 interactions ++
  • Other QTc prolonging agents
  • Recommend review of pt medications due to high frequency of significant interactions

Antimicrobial class: Triazole antifungal, Second generation

Pregnancy category: D

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic