Antimicrobials
Tigecycline

Tigecycline

Restricted

Medium
N/A

Spectrum of Activity

Dosing

General Information

Restricted for use as a last line for patients with multi-drug resistant organism infections or intolerance to other antibiotics.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

  • Avoid or use with caution in patients with tetracycline reactions.
  • GI side effects very prominent with significant nausea and vomiting.
  • Tetracycline related adverse events: photosensitivity, acute pancreatiti.
  • Rash, abnormal liver enzymes.

Oral contraceptives less effective.

Documented safety concerns in bacteremia especially.

Restricted: Consult ID or call pharmacist.

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic