Restricted
Restricted for use as a last line for patients with multi-drug resistant organism infections or intolerance to other antibiotics.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Oral contraceptives less effective.
Documented safety concerns in bacteremia especially.
Restricted: Consult ID or call pharmacist.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Lung penetration: Therapeutic
Biliary penetration: Therapeutic